Simulation scenario 2, CR phase

Setting description

Hormone therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.039, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 25, median = 18	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.85, hr = 0.33	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 291 0 1 0 TP53- & AR- 342 0 1 2 TP53+ 216 0 0 0 DRD+ 108 0 0 0 TEfus+ 162 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.582 0 0.002 0.000 TP53- & AR- 0.684 0 0.002 0.004 TP53+ 0.432 0 0.000 0.000 DRD+ 0.216 0 0.000 0.000 TEfus+ 0.324 0 0.000 0.000

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 105 86 102 TP53- & AR- 2 402 406 419 TP53+ 1 221 224 256 DRD+ 0 162 201 215 TEfus+ 0 233 218 236

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.210 0.172 0.204 TP53- & AR- 0.004 0.804 0.812 0.838 TP53+ 0.002 0.442 0.448 0.512 DRD+ 0.000 0.324 0.402 0.430 TEfus+ 0.000 0.466 0.436 0.472

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 24 15 18 14 TP53+ 58 17 31 25 DRD+ 0 0 0 0 TEfus+ 0 2 1 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.048 0.030 0.036 0.028 TP53+ 0.116 0.034 0.062 0.050 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.000 0.004 0.002 0.000

Errors & power

The overall error was 0.41.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.402             0.000             0.004             0.004 

The overall power was 0.582.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.582             0.000             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	291	0	1	0
	futility	0	0	105	86	102
	max_n	0	0	0	0	0
	n	426 (356, 472)	126 (32, 258)	161 (99, 246)	164 (98, 258)	160 (97, 248)
	n_unique	398 (334, 440)	117 (31, 242)	149 (91, 233)	152 (91, 241)	150 (90, 233)
	time_trial	36 (36, 36)	27 (5, 36)	36 (30, 36)	36 (31, 36)	36 (31, 36)
	time_stop	NA (NA, NA)	9 (4, 29)	30 (17, 36)	30 (19, 35)	31 (21, 36)
	post_p	NA (NA, NA)	1 (1, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)
	rate	0.072 (0.067, 0.078)	0.039 (0.033, 0.044)	0.114 (0.102, 0.127)	0.113 (0.103, 0.129)	0.114 (0.104, 0.128)
TP53- & AR-	graduation	0	342	0	1	2
	futility	0	2	402	406	419
	max_n	0	24	15	18	14
	n	168 (104, 201)	31 (19, 117)	44 (25, 120)	44 (25, 126)	43 (25, 128)
	n_unique	158 (96, 188)	30 (18, 111)	41 (23, 114)	40 (24, 121)	40 (24, 119)
	time_trial	36 (36, 36)	15 (7, 36)	24 (14, 36)	23 (14, 36)	23 (14, 36)
	time_stop	NA (NA, NA)	11 (7, 24)	21 (14, 32)	20 (13, 31)	21 (13, 32)
	post_p	NA (NA, NA)	1 (0.96, 1)	0.01 (0, 0.08)	0.01 (0, 0.09)	0.01 (0, 0.09)
	rate	0.072 (0.063, 0.082)	0.038 (0.029, 0.05)	0.116 (0.097, 0.147)	0.115 (0.098, 0.148)	0.115 (0.098, 0.145)
TP53+	graduation	0	216	0	0	0
	futility	0	1	221	224	256
	max_n	0	58	17	31	25
	n	198 (171, 221)	41 (12, 150)	76 (35, 130)	78 (35, 139)	72 (34, 137)
	n_unique	186 (161, 207)	39 (11, 142)	69 (34, 121)	71 (34, 131)	66 (31, 128)
	time_trial	36 (36, 36)	36 (10, 36)	36 (16, 36)	36 (17, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	14 (9, 28)	23 (12, 34)	25 (14, 34)	25 (14, 34)
	post_p	NA (NA, NA)	1 (0.95, 1)	0 (0, 0.08)	0 (0, 0.08)	0 (0, 0.07)
	rate	0.073 (0.065, 0.083)	0.038 (0.029, 0.047)	0.113 (0.097, 0.137)	0.113 (0.098, 0.137)	0.115 (0.099, 0.142)
DRD+	graduation	0	108	0	0	0
	futility	0	0	162	201	215
	max_n	0	0	0	0	0
	n	109 (90, 130)	25 (1, 54)	50 (27, 78)	54 (32, 84)	54 (30, 80)
	n_unique	102 (84, 121)	22 (1, 51)	46 (25, 73)	50 (30, 78)	50 (28, 76)
	time_trial	36 (36, 36)	36 (23, 36)	36 (26, 36)	36 (19, 36)	36 (17, 36)
	time_stop	NA (NA, NA)	24 (17, 33)	30 (20, 35)	25 (15, 34)	24 (14, 34)
	post_p	NA (NA, NA)	0.98 (0.75, 1)	0.02 (0, 0.17)	0.02 (0, 0.12)	0.02 (0, 0.12)
	rate	0.072 (0.062, 0.084)	0.038 (0.024, 0.057)	0.114 (0.097, 0.147)	0.114 (0.096, 0.138)	0.114 (0.096, 0.149)
TEfus+	graduation	0	162	0	0	0
	futility	0	0	233	218	236
	max_n	0	0	2	1	0
	n	151 (128, 175)	34 (7, 93)	64 (35, 105)	66 (34, 107)	62 (33, 104)
	n_unique	141 (119, 163)	32 (7, 86)	60 (32, 99)	61 (32, 101)	58 (30, 98)
	time_trial	36 (36, 36)	36 (16, 36)	36 (18, 36)	36 (20, 36)	36 (18, 36)
	time_stop	NA (NA, NA)	20 (12, 32)	25 (14, 34)	25 (16, 35)	25 (15, 34)
	post_p	NA (NA, NA)	1 (0.88, 1)	0.01 (0, 0.1)	0.01 (0, 0.09)	0.01 (0, 0.08)
	rate	0.073 (0.063, 0.083)	0.039 (0.026, 0.05)	0.114 (0.096, 0.14)	0.116 (0.096, 0.138)	0.115 (0.097, 0.144)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	470	416	415	424
	futility	0	0	0	0	0
	max_n	0	20	15	18	14
	n	110 (67, 134)	25 (15, 88)	21 (8, 74)	22 (9, 79)	24 (9, 83)
	n_unique	103 (62, 127)	24 (14, 86)	19 (7, 72)	21 (8, 76)	22 (9, 81)
	post_p	NA (NA, NA)	1 (0.91, 1)	0.07 (0, 0.29)	0.06 (0, 0.27)	0.05 (0, 0.29)
	rate	0.073 (0.061, 0.084)	0.039 (0.03, 0.053)	0.116 (0.091, 0.187)	0.118 (0.092, 0.171)	0.116 (0.092, 0.169)
—+	graduation	0	475	435	429	442
	futility	0	0	0	0	0
	max_n	0	19	16	18	13
	n	18 (10, 26)	4 (1, 12)	7 (3, 18)	6 (2, 17)	6 (2, 16)
	n_unique	17 (9, 25)	4 (1, 11)	6 (3, 17)	5 (2, 16)	5 (2, 15)
	post_p	NA (NA, NA)	0.81 (0.48, 0.97)	0.28 (0.11, 0.58)	0.29 (0.12, 0.57)	0.3 (0.1, 0.53)
	rate	0.074 (0.049, 0.115)	0.041 (0.015, 0.094)	0.121 (0.077, 0.245)	0.127 (0.079, 0.345)	0.125 (0.08, 0.268)
–+-	graduation	0	384	225	228	256
	futility	0	0	0	0	0
	max_n	0	57	17	31	25
	n	70 (57, 83)	19 (7, 67)	16 (7, 51)	16 (6, 54)	16 (6, 51)
	n_unique	65 (53, 79)	18 (6, 62)	15 (6, 48)	15 (5, 52)	15 (5, 50)
	post_p	NA (NA, NA)	0.98 (0.76, 1)	0.12 (0.02, 0.36)	0.11 (0.02, 0.39)	0.11 (0.02, 0.36)
	rate	0.072 (0.06, 0.089)	0.039 (0.026, 0.056)	0.12 (0.087, 0.203)	0.116 (0.088, 0.199)	0.12 (0.089, 0.209)
–++	graduation	0	421	299	308	327
	futility	0	0	0	0	0
	max_n	0	57	17	25	22
	n	45 (33, 56)	9 (2, 36)	13 (7, 36)	15 (4, 38)	12 (4, 34)
	n_unique	42 (31, 53)	8 (2, 34)	12 (6, 33)	14 (4, 36)	11 (4, 33)
	post_p	NA (NA, NA)	0.92 (0.58, 1)	0.15 (0.03, 0.43)	0.18 (0.04, 0.46)	0.18 (0.04, 0.46)
	rate	0.074 (0.057, 0.095)	0.038 (0.019, 0.069)	0.12 (0.086, 0.19)	0.118 (0.085, 0.216)	0.12 (0.085, 0.231)
-+–	graduation	0	474	427	432	434
	futility	0	0	0	0	0
	max_n	0	20	13	17	13
	n	18 (11, 26)	2 (0, 9)	7 (2, 18)	7 (3, 20)	7 (3, 18)
	n_unique	17 (10, 24)	2 (0, 8)	6 (2, 17)	7 (3, 18)	7 (3, 17)
	post_p	NA (NA, NA)	0.78 (0.43, 0.96)	0.26 (0.08, 0.54)	0.26 (0.11, 0.57)	0.27 (0.1, 0.52)
	rate	0.072 (0.049, 0.105)	0.04 (0, 0.123)	0.131 (0.083, 0.283)	0.124 (0.077, 0.248)	0.124 (0.081, 0.224)
-+-+	graduation	0	479	445	443	448
	futility	0	0	0	0	0
	max_n	0	19	14	17	12
	n	18 (10, 26)	2 (0, 8)	7 (2, 18)	7 (3, 19)	7 (3, 19)
	n_unique	17 (9, 25)	2 (0, 8)	6 (2, 17)	7 (3, 18)	6 (3, 17)
	post_p	NA (NA, NA)	0.75 (0.44, 0.95)	0.28 (0.11, 0.52)	0.27 (0.09, 0.49)	0.27 (0.09, 0.55)
	rate	0.071 (0.046, 0.101)	0.041 (0, 0.118)	0.126 (0.082, 0.285)	0.125 (0.082, 0.263)	0.124 (0.078, 0.251)
-++-	graduation	0	407	259	285	309
	futility	0	0	0	0	0
	max_n	0	56	17	29	25
	n	12 (8, 17)	2 (0, 8)	5 (1, 12)	5 (2, 13)	5 (2, 12)
	n_unique	11 (7, 16)	2 (0, 8)	5 (1, 11)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.75 (0.46, 0.93)	0.35 (0.16, 0.62)	0.34 (0.14, 0.62)	0.34 (0.15, 0.61)
	rate	0.075 (0.045, 0.123)	0.041 (0, 0.116)	0.13 (0.07, 0.325)	0.127 (0.074, 0.278)	0.127 (0.074, 0.312)
-+++	graduation	0	434	318	339	355
	futility	0	0	0	0	0
	max_n	0	56	17	23	22
	n	12 (7, 16)	2 (0, 7)	4 (1, 12)	5 (2, 12)	5 (2, 12)
	n_unique	11 (6, 16)	2 (0, 7)	4 (1, 11)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.75 (0.43, 0.95)	0.35 (0.16, 0.62)	0.34 (0.14, 0.61)	0.33 (0.14, 0.61)
	rate	0.075 (0.042, 0.126)	0.041 (0, 0.117)	0.126 (0.07, 0.347)	0.123 (0.074, 0.295)	0.13 (0.074, 0.334)
+—	graduation	0	291	105	87	102
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	21 (15, 29)	8 (1, 22)	8 (4, 18)	7 (3, 18)	7 (3, 17)
	n_unique	20 (14, 27)	8 (1, 20)	7 (3, 17)	6 (2, 16)	7 (2, 16)
	post_p	NA (NA, NA)	0.86 (0.5, 0.99)	0.22 (0.08, 0.51)	0.26 (0.1, 0.56)	0.27 (0.1, 0.6)
	rate	0.075 (0.05, 0.104)	0.04 (0.019, 0.089)	0.128 (0.082, 0.246)	0.129 (0.08, 0.327)	0.124 (0.075, 0.295)
+–+	graduation	0	358	239	224	237
	futility	0	0	0	0	0
	max_n	0	0	2	1	0
	n	17 (11, 23)	5 (0, 15)	7 (3, 15)	6 (2, 15)	6 (2, 14)
	n_unique	16 (11, 21)	4 (0, 15)	6 (3, 14)	5 (2, 14)	5 (2, 13)
	post_p	NA (NA, NA)	0.81 (0.48, 0.97)	0.28 (0.12, 0.59)	0.31 (0.14, 0.58)	0.3 (0.14, 0.6)
	rate	0.074 (0.048, 0.11)	0.041 (0.017, 0.099)	0.12 (0.074, 0.25)	0.126 (0.073, 0.318)	0.123 (0.072, 0.317)
+-+-	graduation	0	384	225	228	256
	futility	0	0	0	0	0
	max_n	0	57	17	31	25
	n	17 (11, 23)	3 (0, 14)	7 (3, 15)	6 (2, 15)	6 (2, 15)
	n_unique	16 (10, 22)	3 (0, 13)	6 (2, 14)	6 (2, 14)	6 (2, 14)
	post_p	NA (NA, NA)	0.8 (0.45, 0.97)	0.28 (0.11, 0.57)	0.3 (0.13, 0.59)	0.29 (0.14, 0.55)
	rate	0.075 (0.05, 0.108)	0.041 (0.014, 0.102)	0.128 (0.074, 0.245)	0.126 (0.076, 0.309)	0.135 (0.08, 0.305)
+-++	graduation	0	421	299	308	327
	futility	0	0	0	0	0
	max_n	0	57	17	25	22
	n	17 (11, 23)	3 (0, 12)	7 (3, 16)	6 (2, 15)	6 (2, 15)
	n_unique	15 (10, 22)	3 (0, 11)	7 (3, 16)	6 (2, 13)	6 (2, 15)
	post_p	NA (NA, NA)	0.75 (0.43, 0.97)	0.29 (0.12, 0.62)	0.3 (0.13, 0.62)	0.27 (0.12, 0.56)
	rate	0.073 (0.047, 0.114)	0.042 (0.016, 0.111)	0.122 (0.077, 0.251)	0.126 (0.075, 0.311)	0.134 (0.078, 0.353)
++–	graduation	0	337	180	206	217
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	12 (7, 17)	3 (0, 11)	5 (2, 11)	5 (2, 11)	5 (2, 12)
	n_unique	11 (7, 16)	3 (0, 10)	4 (2, 11)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.75 (0.44, 0.95)	0.33 (0.15, 0.62)	0.32 (0.14, 0.61)	0.34 (0.14, 0.62)
	rate	0.073 (0.042, 0.124)	0.044 (0.013, 0.124)	0.131 (0.068, 0.354)	0.124 (0.075, 0.311)	0.125 (0.072, 0.31)
++-+	graduation	0	388	281	295	299
	futility	0	0	0	0	0
	max_n	0	0	2	1	0
	n	12 (7, 17)	3 (0, 10)	5 (1, 11)	5 (2, 12)	5 (2, 12)
	n_unique	11 (7, 17)	2 (0, 9)	4 (1, 10)	5 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.76 (0.5, 0.95)	0.34 (0.16, 0.63)	0.34 (0.15, 0.6)	0.34 (0.17, 0.6)
	rate	0.075 (0.043, 0.126)	0.04 (0.011, 0.089)	0.128 (0.072, 0.382)	0.127 (0.073, 0.279)	0.131 (0.074, 0.277)
+++-	graduation	0	407	259	285	309
	futility	0	0	0	0	0
	max_n	0	56	17	29	25
	n	12 (7, 17)	2 (0, 8)	5 (1, 12)	6 (2, 12)	5 (2, 12)
	n_unique	11 (7, 16)	1 (0, 8)	4 (1, 11)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.74 (0.42, 0.93)	0.35 (0.16, 0.64)	0.33 (0.16, 0.62)	0.31 (0.16, 0.6)
	rate	0.073 (0.043, 0.122)	0.04 (0, 0.115)	0.128 (0.069, 0.342)	0.122 (0.075, 0.268)	0.127 (0.077, 0.326)
++++	graduation	0	434	318	339	355
	futility	0	0	0	0	0
	max_n	0	56	17	23	22
	n	12 (7, 17)	2 (0, 8)	5 (1, 11)	5 (2, 12)	5 (2, 12)
	n_unique	11 (7, 17)	1 (0, 7)	4 (1, 11)	5 (2, 12)	4 (2, 12)
	post_p	NA (NA, NA)	0.73 (0.41, 0.94)	0.37 (0.17, 0.65)	0.34 (0.16, 0.62)	0.33 (0.16, 0.57)
	rate	0.074 (0.043, 0.122)	0.039 (0, 0.123)	0.127 (0.068, 0.366)	0.12 (0.07, 0.322)	0.125 (0.074, 0.301)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Carboplatin	Niraparib
all	count	291	1
	time_stop	9 (4, 29)	6 (6, 6)
	n_trt	63 (29, 190)	25 (25, 25)
	n_control	89 (46, 326)	70 (70, 70)
	post_p	1 (0.9, 1)	0.98 (0.98, 0.98)
	order	1 (1, 3)	1 (1, 1)
TP53- & AR-	count	342	1	2
	time_stop	11 (7, 24)	15 (15, 15)	14 (12, 17)
	n_trt	36 (26, 96)	37 (37, 37)	38 (31, 46)
	n_control	45 (27, 111)	70 (70, 70)	60 (46, 74)
	post_p	0.96 (0.89, 1)	0.85 (0.85, 0.85)	0.89 (0.88, 0.89)
	order	1 (1, 2)	3 (3, 3)	2 (2, 2)
TP53+	count	216
	time_stop	14 (9, 28)
	n_trt	42 (27, 114)
	n_control	60 (36, 145)
	post_p	0.99 (0.93, 1)
	order	2 (1, 3.5)
DRD+	count	108
	time_stop	24 (17, 33)
	n_trt	30 (25, 46)
	n_control	66 (41, 98)
	post_p	1 (0.96, 1)
	order	3 (1, 4)
TEfus+	count	162
	time_stop	20 (12, 32)
	n_trt	38 (26, 83)
	n_control	74 (39, 132)
	post_p	1 (0.95, 1)
	order	3 (1, 5)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count		105	86	102
	time_stop		30 (17, 36)	30 (20, 35)	31 (21, 36)
	n_trt		116 (68, 193)	123 (72, 182)	114 (80, 197)
	n_control		348 (184, 429)	342 (211, 424)	347 (245, 431)
	post_p		0 (0, 0)	0 (0, 0)	0 (0, 0)
	order		6 (2, 9)	6 (3, 9)	7 (4, 10)
TP53- & AR-	count	2	402	406	419
	time_stop	6 (5, 8)	21 (14, 32)	20 (13, 31)	21 (13, 32)
	n_trt	26 (26, 27)	40 (25, 96)	38 (25, 102)	40 (25, 103)
	n_control	26 (24, 27)	103 (61, 163)	93 (54, 162)	99 (55, 167)
	post_p	0.27 (0.25, 0.29)	0.05 (0, 0.17)	0.05 (0, 0.18)	0.05 (0, 0.18)
	order	1 (1, 1)	3 (1, 6)	3 (1, 6)	3 (1, 6.2)
TP53+	count	1	221	224	256
	time_stop	9 (9, 9)	23 (12, 34)	25 (14, 34)	25 (14, 34)
	n_trt	26 (26, 26)	55 (28, 103)	56 (29, 110)	53 (28, 102)
	n_control	35 (35, 35)	119 (49, 185)	129 (62, 190)	122 (65, 186)
	post_p	0.29 (0.29, 0.29)	0.01 (0, 0.08)	0.01 (0, 0.06)	0.01 (0, 0.07)
	order	1 (1, 1)	4 (1, 9)	4 (1, 8)	4 (1, 9)
DRD+	count		162	201	215
	time_stop		30 (20, 35)	25 (15, 34)	24 (14, 34)
	n_trt		41 (26, 65)	44 (28, 62)	39 (26, 65)
	n_control		90 (54, 117)	74 (41, 105)	70 (37, 111)
	post_p		0.01 (0, 0.05)	0.01 (0, 0.09)	0.02 (0, 0.09)
	order		6.5 (3, 11)	5 (2, 8)	5 (2, 9)
TEfus+	count		233	218	236
	time_stop		25 (14, 34)	25 (16, 35)	25 (15, 34)
	n_trt		52 (29, 82)	49 (29, 87)	46 (28, 84)
	n_control		102 (48, 153)	105 (57, 150)	102 (54, 148)
	post_p		0.01 (0, 0.06)	0.01 (0, 0.06)	0.01 (0, 0.07)
	order		5 (1, 9)	5 (2, 9.3)	5 (2, 9)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	291	291	291	291	291	291	291	291	291	291	291	291	291	291	291	291
		time	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)	9 (4, 29)
		n	22 (14, 58)	4 (1, 10)	13 (5, 44)	5 (1, 23)	1 (0, 6)	1 (0, 6)	1 (0, 5)	1 (0, 5)	3 (0, 12)	2 (0, 10)	2 (0, 9)	2 (0, 7)	1 (0, 6)	1 (0, 6)	1 (0, 5)	1 (0, 5)
		post_p	0.81 (0.57, 1)	0.58 (0.52, 0.88)	0.74 (0.54, 1)	0.62 (0.52, 0.97)	0.63 (0.52, 0.94)	0.6 (0.52, 0.9)	0.61 (0.51, 0.87)	0.63 (0.52, 0.9)	0.59 (0.51, 0.94)	0.6 (0.51, 0.9)	0.6 (0.52, 0.88)	0.59 (0.52, 0.88)	0.6 (0.52, 0.87)	0.63 (0.52, 0.89)	0.61 (0.52, 0.87)	0.62 (0.52, 0.85)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.033 (0, 0.054)	0.016 (0, 0.077)	0.033 (0, 0.062)	0.024 (0, 0.071)	0 (0, 0.071)	0.006 (0, 0.069)	0 (0, 0.075)	0 (0, 0.064)	0.017 (0, 0.079)	0 (0, 0.073)	0 (0, 0.067)	0 (0, 0.076)	0 (0, 0.082)	0.016 (0, 0.079)	0 (0, 0.072)	0 (0, 0.06)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	4 (4, 4)	1 (1, 1)	1 (1, 1)	3 (3, 3)	5 (5, 5)	2 (2, 2)	0 (0, 0)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	1 (1, 1)	2 (2, 2)	1 (1, 1)
		post_p	0.64 (0.64, 0.64)	0.55 (0.55, 0.55)	0.54 (0.54, 0.54)	0.53 (0.53, 0.53)	0.63 (0.63, 0.63)	0.59 (0.59, 0.59)	NA (NA, NA)	0.5 (0.5, 0.5)	0.63 (0.63, 0.63)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.5 (0.5, 0.5)	NA (NA, NA)	0.6 (0.6, 0.6)	0.51 (0.51, 0.51)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	342	342			342	342
		time	11 (7, 24)	11 (7, 24)			11 (7, 24)	11 (7, 24)
		n	28 (20, 72)	4 (2, 11)			2 (0, 8)	2 (0, 8)
		post_p	0.9 (0.74, 1)	0.59 (0.52, 0.82)			0.6 (0.52, 0.85)	0.58 (0.52, 0.85)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.037 (0.014, 0.051)	0.025 (0, 0.09)			0 (0, 0.086)	0 (0, 0.074)
	Carboplatin	count	1	1			1	1
		time	15 (15, 15)	15 (15, 15)			15 (15, 15)	15 (15, 15)
		n	25 (25, 25)	2 (2, 2)			5 (5, 5)	5 (5, 5)
		post_p	0.77 (0.77, 0.77)	0.58 (0.58, 0.58)			0.56 (0.56, 0.56)	0.69 (0.69, 0.69)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.052 (0.052, 0.052)	0 (0, 0)			0.068 (0.068, 0.068)	0.028 (0.028, 0.028)
	Niraparib	count	2	2			2	2
		time	14 (12, 17)	14 (12, 17)			14 (12, 17)	14 (12, 17)
		n	24 (18, 30)	3 (2, 4)			8 (6, 11)	3 (3, 3)
		post_p	0.83 (0.82, 0.84)	0.55 (0.54, 0.56)			0.8 (0.76, 0.84)	0.58 (0.57, 0.59)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.058 (0.045, 0.072)	0.05 (0.01, 0.09)			0.058 (0.044, 0.073)	0.079 (0.066, 0.092)
TP53+	Hormone_therapies	count			216	216			216	216			216	216			216	216
		time			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)			14 (9, 28)	14 (9, 28)
		n			20 (12, 50)	9 (4, 27)			2 (0, 6)	2 (0, 5)			4 (1, 10)	3 (1, 8)			2 (0, 6)	2 (0, 6)
		post_p			0.87 (0.72, 1)	0.78 (0.58, 0.97)			0.6 (0.52, 0.83)	0.61 (0.52, 0.84)			0.65 (0.52, 0.9)	0.62 (0.52, 0.85)			0.59 (0.52, 0.84)	0.6 (0.52, 0.84)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.035 (0.015, 0.057)	0.033 (0, 0.062)			0 (0, 0.074)	0 (0, 0.075)			0.015 (0, 0.072)	0.023 (0, 0.086)			0 (0, 0.08)	0 (0, 0.075)
DRD+		count					108	108	108	108					108	108	108	108
		time					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)					24 (17, 33)	24 (17, 33)	24 (17, 33)	24 (17, 33)
		n					4 (1, 10)	4 (1, 9)	3 (1, 7)	3 (1, 7)					5 (1, 10)	4 (1, 9)	3 (1, 8)	3 (0, 8)
		post_p					0.77 (0.58, 0.97)	0.75 (0.53, 0.92)	0.68 (0.52, 0.89)	0.69 (0.53, 0.88)					0.73 (0.55, 0.93)	0.72 (0.54, 0.94)	0.71 (0.54, 0.88)	0.69 (0.53, 0.85)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.031 (0, 0.079)	0.035 (0, 0.066)	0.029 (0, 0.088)	0.028 (0, 0.092)					0.03 (0, 0.084)	0.027 (0, 0.074)	0.032 (0, 0.085)	0.029 (0, 0.082)
TEfus+		count		162		162		162		162		162		162		162		162
		time		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)		20 (12, 32)
		n		5 (2, 13)		12 (5, 31)		3 (0, 8)		3 (0, 6)		5 (2, 13)		4 (1, 10)		3 (1, 8)		2 (0, 7)
		post_p		0.74 (0.52, 0.95)		0.85 (0.71, 0.99)		0.7 (0.53, 0.9)		0.64 (0.54, 0.87)		0.74 (0.54, 0.93)		0.71 (0.54, 0.93)		0.66 (0.53, 0.86)		0.64 (0.52, 0.87)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.037 (0, 0.083)		0.036 (0.013, 0.066)		0.032 (0, 0.072)		0.02 (0, 0.086)		0.03 (0, 0.073)		0.03 (0, 0.072)		0.019 (0, 0.082)		0.021 (0, 0.077)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Taxel_therapies	count	105	105	105	105	105	105	105	105	105	105	105	105	105	105	105	105
		time	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)	30 (17, 36)
		n	15 (7, 58)	6 (3, 14)	12 (5, 45)	10 (7, 28)	6 (2, 14)	5 (1, 15)	3 (0, 9)	3 (0, 9)	7 (3, 13)	5 (2, 10)	6 (2, 14)	5 (2, 11)	4 (1, 10)	4 (0, 10)	3 (0, 8)	3 (0, 7)
		post_p	0.09 (0.01, 0.35)	0.31 (0.12, 0.48)	0.17 (0.04, 0.42)	0.21 (0.05, 0.41)	0.31 (0.09, 0.47)	0.28 (0.15, 0.46)	0.35 (0.19, 0.47)	0.38 (0.17, 0.48)	0.26 (0.1, 0.46)	0.28 (0.16, 0.46)	0.32 (0.17, 0.48)	0.28 (0.09, 0.47)	0.36 (0.19, 0.47)	0.35 (0.2, 0.48)	0.35 (0.19, 0.47)	0.35 (0.17, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.125 (0.092, 0.202)	0.13 (0.084, 0.248)	0.123 (0.09, 0.2)	0.121 (0.085, 0.189)	0.135 (0.094, 0.29)	0.139 (0.088, 0.285)	0.156 (0.085, 0.369)	0.153 (0.088, 0.383)	0.138 (0.081, 0.3)	0.151 (0.082, 0.329)	0.12 (0.076, 0.295)	0.151 (0.08, 0.291)	0.151 (0.083, 0.487)	0.146 (0.087, 0.439)	0.153 (0.084, 0.531)	0.172 (0.091, 0.64)
	Carboplatin	count	86	86	86	86	86	86	86	86	86	86	86	86	86	86	86	86
		time	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)
		n	16 (8, 47)	5 (2, 13)	12 (5, 40)	9 (4, 28)	6 (3, 12)	6 (3, 12)	4 (2, 8)	4 (1, 8)	5 (2, 16)	4 (2, 8)	4 (1, 13)	4 (2, 11)	4 (2, 8)	4 (2, 10)	4 (2, 8)	4 (1, 7)
		post_p	0.12 (0.02, 0.3)	0.31 (0.13, 0.46)	0.17 (0.05, 0.38)	0.22 (0.05, 0.43)	0.26 (0.11, 0.46)	0.29 (0.14, 0.44)	0.33 (0.16, 0.47)	0.34 (0.18, 0.47)	0.26 (0.12, 0.46)	0.32 (0.17, 0.44)	0.32 (0.16, 0.45)	0.32 (0.17, 0.47)	0.34 (0.17, 0.46)	0.33 (0.14, 0.47)	0.34 (0.2, 0.49)	0.34 (0.2, 0.47)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.12 (0.093, 0.175)	0.132 (0.088, 0.282)	0.117 (0.089, 0.235)	0.129 (0.085, 0.242)	0.147 (0.09, 0.27)	0.135 (0.093, 0.304)	0.134 (0.079, 0.27)	0.137 (0.089, 0.277)	0.151 (0.085, 0.529)	0.148 (0.085, 0.374)	0.154 (0.096, 0.371)	0.149 (0.086, 0.324)	0.137 (0.08, 0.289)	0.153 (0.084, 0.415)	0.132 (0.086, 0.398)	0.132 (0.075, 0.388)
	Niraparib	count	102	102	102	102	102	102	102	102	102	102	102	102	102	102	102	102
		time	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)	31 (21, 36)
		n	23 (10, 60)	5 (2, 13)	13 (5, 35)	8 (4, 28)	6 (3, 14)	6 (2, 12)	4 (1, 9)	4 (1, 9)	7 (3, 14)	4 (1, 13)	4 (2, 10)	4 (2, 11)	4 (2, 9)	4 (2, 8)	4 (2, 9)	4 (2, 8)
		post_p	0.1 (0.01, 0.35)	0.34 (0.13, 0.46)	0.14 (0.03, 0.38)	0.21 (0.07, 0.44)	0.31 (0.11, 0.45)	0.25 (0.1, 0.44)	0.34 (0.17, 0.45)	0.3 (0.15, 0.46)	0.27 (0.13, 0.47)	0.32 (0.17, 0.47)	0.28 (0.14, 0.46)	0.28 (0.14, 0.45)	0.36 (0.14, 0.46)	0.35 (0.21, 0.48)	0.35 (0.2, 0.47)	0.33 (0.15, 0.46)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.113 (0.093, 0.153)	0.12 (0.085, 0.247)	0.125 (0.087, 0.255)	0.125 (0.087, 0.267)	0.129 (0.083, 0.211)	0.153 (0.091, 0.285)	0.169 (0.084, 0.513)	0.165 (0.092, 0.529)	0.124 (0.085, 0.289)	0.146 (0.083, 0.342)	0.154 (0.089, 0.42)	0.155 (0.093, 0.424)	0.133 (0.086, 0.4)	0.145 (0.082, 0.333)	0.147 (0.088, 0.343)	0.147 (0.084, 0.317)
TP53- & AR-	Hormone_therapies	count	2	2			2	2
		time	6 (5, 8)	6 (5, 8)			6 (5, 8)	6 (5, 8)
		n	20 (20, 21)	4 (4, 5)			0 (0, 1)	1 (0, 2)
		post_p	0.34 (0.26, 0.41)	0.42 (0.42, 0.42)			0.42 (0.42, 0.42)	0.49 (0.49, 0.49)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.085 (0.07, 0.1)	0.173 (0.133, 0.213)			20.808 (20.808, 20.808)	0 (0, 0)
	Taxel_therapies	count	402	402			402	402
		time	21 (14, 32)	21 (14, 32)			21 (14, 32)	21 (14, 32)
		n	19 (9, 60)	6 (3, 14)			6 (2, 15)	6 (2, 15)
		post_p	0.17 (0.02, 0.41)	0.35 (0.15, 0.48)			0.37 (0.16, 0.48)	0.38 (0.19, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.113 (0.086, 0.179)	0.121 (0.08, 0.247)			0.133 (0.086, 0.319)	0.131 (0.084, 0.324)
	Carboplatin	count	406	406			406	406
		time	20 (13, 31)	20 (13, 31)			20 (13, 31)	20 (13, 31)
		n	18 (9, 66)	5 (2, 14)			7 (3, 16)	7 (3, 15)
		post_p	0.2 (0.02, 0.43)	0.37 (0.16, 0.48)			0.35 (0.14, 0.48)	0.37 (0.15, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.111 (0.087, 0.165)	0.132 (0.084, 0.368)			0.127 (0.084, 0.254)	0.124 (0.081, 0.285)
	Niraparib	count	419	419			419	419
		time	21 (13, 32)	21 (13, 32)			21 (13, 32)	21 (13, 32)
		n	21 (9, 66)	5 (2, 14)			7 (3, 15)	6 (3, 16)
		post_p	0.19 (0.02, 0.43)	0.38 (0.15, 0.48)			0.36 (0.15, 0.48)	0.35 (0.14, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.112 (0.085, 0.181)	0.131 (0.082, 0.3)			0.128 (0.083, 0.227)	0.128 (0.085, 0.27)
TP53+	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n			10 (10, 10)	11 (11, 11)			0 (0, 0)	3 (3, 3)			2 (2, 2)	0 (0, 0)			0 (0, 0)	0 (0, 0)
		post_p			0.44 (0.44, 0.44)	0.38 (0.38, 0.38)			NA (NA, NA)	0.34 (0.34, 0.34)			0.43 (0.43, 0.43)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.073 (0.073, 0.073)	0.058 (0.058, 0.058)			NA (NA, NA)	0.233 (0.233, 0.233)			0.25 (0.25, 0.25)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count			221	221			221	221			221	221			221	221
		time			23 (12, 34)	23 (12, 34)			23 (12, 34)	23 (12, 34)			23 (12, 34)	23 (12, 34)			23 (12, 34)	23 (12, 34)
		n			12 (6, 39)	11 (6, 28)			3 (1, 9)	3 (0, 9)			5 (2, 12)	5 (3, 11)			3 (1, 8)	3 (0, 9)
		post_p			0.18 (0.04, 0.41)	0.22 (0.05, 0.44)			0.39 (0.2, 0.48)	0.39 (0.22, 0.48)			0.34 (0.16, 0.47)	0.35 (0.14, 0.47)			0.39 (0.21, 0.48)	0.37 (0.21, 0.47)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.121 (0.087, 0.215)	0.121 (0.085, 0.2)			0.153 (0.086, 0.437)	0.15 (0.083, 0.356)			0.135 (0.079, 0.31)	0.133 (0.08, 0.281)			0.152 (0.086, 0.529)	0.162 (0.084, 0.566)
	Carboplatin	count			224	224			224	224			224	224			224	224
		time			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)
		n			12 (5, 42)	10 (4, 29)			4 (2, 9)	4 (1, 9)			4 (2, 12)	5 (2, 11)			4 (2, 9)	4 (2, 9)
		post_p			0.18 (0.05, 0.42)	0.27 (0.07, 0.47)			0.38 (0.17, 0.48)	0.37 (0.18, 0.48)			0.34 (0.16, 0.46)	0.35 (0.2, 0.47)			0.37 (0.22, 0.49)	0.36 (0.19, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.117 (0.085, 0.215)	0.12 (0.086, 0.267)			0.133 (0.078, 0.331)	0.14 (0.085, 0.329)			0.154 (0.086, 0.413)	0.143 (0.094, 0.417)			0.131 (0.083, 0.273)	0.139 (0.078, 0.37)
	Niraparib	count			256	256			256	256			256	256			256	256
		time			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)			25 (14, 34)	25 (14, 34)
		n			13 (5, 37)	9 (3, 28)			4 (1, 9)	4 (2, 10)			4 (2, 12)	4 (1, 12)			4 (2, 8)	4 (2, 10)
		post_p			0.19 (0.04, 0.43)	0.27 (0.07, 0.45)			0.38 (0.18, 0.48)	0.36 (0.16, 0.47)			0.36 (0.17, 0.47)	0.35 (0.13, 0.47)			0.38 (0.21, 0.48)	0.36 (0.18, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.12 (0.085, 0.229)	0.12 (0.086, 0.278)			0.137 (0.079, 0.435)	0.15 (0.077, 0.428)			0.142 (0.09, 0.418)	0.148 (0.089, 0.424)			0.144 (0.086, 0.348)	0.144 (0.078, 0.319)
DRD+	Taxel_therapies	count					162	162	162	162					162	162	162	162
		time					30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)					30 (20, 35)	30 (20, 35)	30 (20, 35)	30 (20, 35)
		n					7 (3, 15)	7 (2, 17)	4 (1, 9)	3 (1, 9)					5 (2, 9)	4 (1, 10)	3 (1, 8)	3 (1, 8)
		post_p					0.33 (0.09, 0.46)	0.29 (0.14, 0.46)	0.36 (0.18, 0.48)	0.36 (0.17, 0.47)					0.37 (0.17, 0.47)	0.37 (0.2, 0.48)	0.36 (0.21, 0.47)	0.35 (0.18, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.13 (0.091, 0.282)	0.129 (0.088, 0.282)	0.157 (0.085, 0.434)	0.152 (0.088, 0.358)					0.138 (0.083, 0.334)	0.139 (0.086, 0.376)	0.151 (0.085, 0.458)	0.161 (0.092, 0.575)
	Carboplatin	count					201	201	201	201					201	201	201	201
		time					25 (15, 34)	25 (15, 34)	25 (15, 34)	25 (15, 34)					25 (15, 34)	25 (15, 34)	25 (15, 34)	25 (15, 34)
		n					6 (3, 14)	6 (3, 13)	4 (2, 9)	4 (2, 9)					5 (2, 9)	4 (2, 10)	4 (2, 8)	4 (2, 9)
		post_p					0.31 (0.12, 0.47)	0.31 (0.11, 0.45)	0.36 (0.18, 0.48)	0.38 (0.18, 0.48)					0.37 (0.2, 0.47)	0.38 (0.16, 0.48)	0.38 (0.19, 0.48)	0.38 (0.21, 0.48)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.132 (0.087, 0.256)	0.128 (0.083, 0.309)	0.14 (0.082, 0.315)	0.136 (0.083, 0.323)					0.129 (0.078, 0.289)	0.148 (0.078, 0.358)	0.132 (0.085, 0.34)	0.129 (0.072, 0.39)
	Niraparib	count					215	215	215	215					215	215	215	215
		time					24 (14, 34)	24 (14, 34)	24 (14, 34)	24 (14, 34)					24 (14, 34)	24 (14, 34)	24 (14, 34)	24 (14, 34)
		n					6 (3, 14)	6 (2, 13)	4 (2, 9)	4 (2, 9)					4 (2, 9)	4 (2, 8)	4 (2, 8)	4 (2, 9)
		post_p					0.33 (0.12, 0.48)	0.3 (0.11, 0.46)	0.39 (0.2, 0.48)	0.36 (0.17, 0.48)					0.37 (0.18, 0.48)	0.36 (0.21, 0.48)	0.37 (0.2, 0.48)	0.36 (0.18, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.132 (0.089, 0.238)	0.144 (0.088, 0.285)	0.145 (0.075, 0.433)	0.149 (0.08, 0.436)					0.14 (0.081, 0.401)	0.148 (0.08, 0.323)	0.144 (0.087, 0.381)	0.14 (0.078, 0.368)
TEfus+	Taxel_therapies	count		233		233		233		233		233		233		233		233
		time		25 (14, 34)		25 (14, 34)		25 (14, 34)		25 (14, 34)		25 (14, 34)		25 (14, 34)		25 (14, 34)		25 (14, 34)
		n		6 (3, 14)		11 (6, 28)		6 (2, 15)		3 (1, 9)		6 (2, 10)		6 (3, 12)		4 (1, 9)		3 (1, 9)
		post_p		0.34 (0.14, 0.47)		0.19 (0.05, 0.44)		0.35 (0.17, 0.47)		0.38 (0.2, 0.48)		0.32 (0.15, 0.47)		0.32 (0.14, 0.46)		0.38 (0.21, 0.48)		0.38 (0.21, 0.47)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.126 (0.08, 0.233)		0.119 (0.086, 0.198)		0.131 (0.084, 0.335)		0.143 (0.085, 0.381)		0.143 (0.079, 0.331)		0.136 (0.083, 0.253)		0.151 (0.081, 0.579)		0.154 (0.085, 0.513)
	Carboplatin	count		218		218		218		218		218		218		218		218
		time		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)		25 (16, 35)
		n		5 (2, 13)		11 (4, 33)		6 (3, 13)		4 (2, 10)		4 (2, 10)		5 (2, 12)		4 (2, 11)		4 (2, 9)
		post_p		0.33 (0.16, 0.46)		0.24 (0.05, 0.47)		0.31 (0.12, 0.46)		0.37 (0.18, 0.48)		0.36 (0.18, 0.48)		0.36 (0.17, 0.48)		0.36 (0.17, 0.47)		0.37 (0.19, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.135 (0.088, 0.369)		0.122 (0.087, 0.271)		0.129 (0.087, 0.32)		0.139 (0.081, 0.334)		0.14 (0.084, 0.405)		0.139 (0.084, 0.318)		0.144 (0.08, 0.339)		0.131 (0.075, 0.369)
	Niraparib	count		236		236		236		236		236		236		236		236
		time		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)		25 (15, 34)
		n		5 (2, 12)		9 (4, 28)		6 (3, 16)		4 (1, 10)		5 (2, 13)		4 (2, 11)		4 (2, 8)		4 (2, 9)
		post_p		0.35 (0.17, 0.48)		0.26 (0.09, 0.46)		0.32 (0.12, 0.46)		0.35 (0.16, 0.48)		0.37 (0.17, 0.48)		0.32 (0.13, 0.47)		0.37 (0.2, 0.48)		0.36 (0.18, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.125 (0.082, 0.25)		0.121 (0.085, 0.267)		0.134 (0.084, 0.272)		0.149 (0.08, 0.428)		0.131 (0.083, 0.343)		0.15 (0.089, 0.422)		0.143 (0.083, 0.323)		0.14 (0.083, 0.317)