Setting description

Hormone therapies more effective in all the biomarker signatures

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.039, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 25, median = 18 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.85, hr = 0.33 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 291 0 1 0
TP53- & AR- 342 0 1 2
TP53+ 216 0 0 0
DRD+ 108 0 0 0
TEfus+ 162 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.582 0 0.002 0.000
TP53- & AR- 0.684 0 0.002 0.004
TP53+ 0.432 0 0.000 0.000
DRD+ 0.216 0 0.000 0.000
TEfus+ 0.324 0 0.000 0.000
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 105 86 102
TP53- & AR- 2 402 406 419
TP53+ 1 221 224 256
DRD+ 0 162 201 215
TEfus+ 0 233 218 236
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.210 0.172 0.204
TP53- & AR- 0.004 0.804 0.812 0.838
TP53+ 0.002 0.442 0.448 0.512
DRD+ 0.000 0.324 0.402 0.430
TEfus+ 0.000 0.466 0.436 0.472
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 24 15 18 14
TP53+ 58 17 31 25
DRD+ 0 0 0 0
TEfus+ 0 2 1 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.048 0.030 0.036 0.028
TP53+ 0.116 0.034 0.062 0.050
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.000 0.004 0.002 0.000


Errors & power

The overall error was 0.41.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.402             0.000             0.004             0.004 

The overall power was 0.582.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.582             0.000             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 291 0 1 0
futility 0 0 105 86 102
max_n 0 0 0 0 0
n 426 (356, 472) 126 (32, 258) 161 (99, 246) 164 (98, 258) 160 (97, 248)
n_unique 398 (334, 440) 117 (31, 242) 149 (91, 233) 152 (91, 241) 150 (90, 233)
time_trial 36 (36, 36) 27 (5, 36) 36 (30, 36) 36 (31, 36) 36 (31, 36)
time_stop NA (NA, NA) 9 (4, 29) 30 (17, 36) 30 (19, 35) 31 (21, 36)
post_p NA (NA, NA) 1 (1, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.072 (0.067, 0.078) 0.039 (0.033, 0.044) 0.114 (0.102, 0.127) 0.113 (0.103, 0.129) 0.114 (0.104, 0.128)
TP53- & AR- graduation 0 342 0 1 2
futility 0 2 402 406 419
max_n 0 24 15 18 14
n 168 (104, 201) 31 (19, 117) 44 (25, 120) 44 (25, 126) 43 (25, 128)
n_unique 158 (96, 188) 30 (18, 111) 41 (23, 114) 40 (24, 121) 40 (24, 119)
time_trial 36 (36, 36) 15 (7, 36) 24 (14, 36) 23 (14, 36) 23 (14, 36)
time_stop NA (NA, NA) 11 (7, 24) 21 (14, 32) 20 (13, 31) 21 (13, 32)
post_p NA (NA, NA) 1 (0.96, 1) 0.01 (0, 0.08) 0.01 (0, 0.09) 0.01 (0, 0.09)
rate 0.072 (0.063, 0.082) 0.038 (0.029, 0.05) 0.116 (0.097, 0.147) 0.115 (0.098, 0.148) 0.115 (0.098, 0.145)
TP53+ graduation 0 216 0 0 0
futility 0 1 221 224 256
max_n 0 58 17 31 25
n 198 (171, 221) 41 (12, 150) 76 (35, 130) 78 (35, 139) 72 (34, 137)
n_unique 186 (161, 207) 39 (11, 142) 69 (34, 121) 71 (34, 131) 66 (31, 128)
time_trial 36 (36, 36) 36 (10, 36) 36 (16, 36) 36 (17, 36) 36 (17, 36)
time_stop NA (NA, NA) 14 (9, 28) 23 (12, 34) 25 (14, 34) 25 (14, 34)
post_p NA (NA, NA) 1 (0.95, 1) 0 (0, 0.08) 0 (0, 0.08) 0 (0, 0.07)
rate 0.073 (0.065, 0.083) 0.038 (0.029, 0.047) 0.113 (0.097, 0.137) 0.113 (0.098, 0.137) 0.115 (0.099, 0.142)
DRD+ graduation 0 108 0 0 0
futility 0 0 162 201 215
max_n 0 0 0 0 0
n 109 (90, 130) 25 (1, 54) 50 (27, 78) 54 (32, 84) 54 (30, 80)
n_unique 102 (84, 121) 22 (1, 51) 46 (25, 73) 50 (30, 78) 50 (28, 76)
time_trial 36 (36, 36) 36 (23, 36) 36 (26, 36) 36 (19, 36) 36 (17, 36)
time_stop NA (NA, NA) 24 (17, 33) 30 (20, 35) 25 (15, 34) 24 (14, 34)
post_p NA (NA, NA) 0.98 (0.75, 1) 0.02 (0, 0.17) 0.02 (0, 0.12) 0.02 (0, 0.12)
rate 0.072 (0.062, 0.084) 0.038 (0.024, 0.057) 0.114 (0.097, 0.147) 0.114 (0.096, 0.138) 0.114 (0.096, 0.149)
TEfus+ graduation 0 162 0 0 0
futility 0 0 233 218 236
max_n 0 0 2 1 0
n 151 (128, 175) 34 (7, 93) 64 (35, 105) 66 (34, 107) 62 (33, 104)
n_unique 141 (119, 163) 32 (7, 86) 60 (32, 99) 61 (32, 101) 58 (30, 98)
time_trial 36 (36, 36) 36 (16, 36) 36 (18, 36) 36 (20, 36) 36 (18, 36)
time_stop NA (NA, NA) 20 (12, 32) 25 (14, 34) 25 (16, 35) 25 (15, 34)
post_p NA (NA, NA) 1 (0.88, 1) 0.01 (0, 0.1) 0.01 (0, 0.09) 0.01 (0, 0.08)
rate 0.073 (0.063, 0.083) 0.039 (0.026, 0.05) 0.114 (0.096, 0.14) 0.116 (0.096, 0.138) 0.115 (0.097, 0.144)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 470 416 415 424
futility 0 0 0 0 0
max_n 0 20 15 18 14
n 110 (67, 134) 25 (15, 88) 21 (8, 74) 22 (9, 79) 24 (9, 83)
n_unique 103 (62, 127) 24 (14, 86) 19 (7, 72) 21 (8, 76) 22 (9, 81)
post_p NA (NA, NA) 1 (0.91, 1) 0.07 (0, 0.29) 0.06 (0, 0.27) 0.05 (0, 0.29)
rate 0.073 (0.061, 0.084) 0.039 (0.03, 0.053) 0.116 (0.091, 0.187) 0.118 (0.092, 0.171) 0.116 (0.092, 0.169)
—+ graduation 0 475 435 429 442
futility 0 0 0 0 0
max_n 0 19 16 18 13
n 18 (10, 26) 4 (1, 12) 7 (3, 18) 6 (2, 17) 6 (2, 16)
n_unique 17 (9, 25) 4 (1, 11) 6 (3, 17) 5 (2, 16) 5 (2, 15)
post_p NA (NA, NA) 0.81 (0.48, 0.97) 0.28 (0.11, 0.58) 0.29 (0.12, 0.57) 0.3 (0.1, 0.53)
rate 0.074 (0.049, 0.115) 0.041 (0.015, 0.094) 0.121 (0.077, 0.245) 0.127 (0.079, 0.345) 0.125 (0.08, 0.268)
–+- graduation 0 384 225 228 256
futility 0 0 0 0 0
max_n 0 57 17 31 25
n 70 (57, 83) 19 (7, 67) 16 (7, 51) 16 (6, 54) 16 (6, 51)
n_unique 65 (53, 79) 18 (6, 62) 15 (6, 48) 15 (5, 52) 15 (5, 50)
post_p NA (NA, NA) 0.98 (0.76, 1) 0.12 (0.02, 0.36) 0.11 (0.02, 0.39) 0.11 (0.02, 0.36)
rate 0.072 (0.06, 0.089) 0.039 (0.026, 0.056) 0.12 (0.087, 0.203) 0.116 (0.088, 0.199) 0.12 (0.089, 0.209)
–++ graduation 0 421 299 308 327
futility 0 0 0 0 0
max_n 0 57 17 25 22
n 45 (33, 56) 9 (2, 36) 13 (7, 36) 15 (4, 38) 12 (4, 34)
n_unique 42 (31, 53) 8 (2, 34) 12 (6, 33) 14 (4, 36) 11 (4, 33)
post_p NA (NA, NA) 0.92 (0.58, 1) 0.15 (0.03, 0.43) 0.18 (0.04, 0.46) 0.18 (0.04, 0.46)
rate 0.074 (0.057, 0.095) 0.038 (0.019, 0.069) 0.12 (0.086, 0.19) 0.118 (0.085, 0.216) 0.12 (0.085, 0.231)
-+– graduation 0 474 427 432 434
futility 0 0 0 0 0
max_n 0 20 13 17 13
n 18 (11, 26) 2 (0, 9) 7 (2, 18) 7 (3, 20) 7 (3, 18)
n_unique 17 (10, 24) 2 (0, 8) 6 (2, 17) 7 (3, 18) 7 (3, 17)
post_p NA (NA, NA) 0.78 (0.43, 0.96) 0.26 (0.08, 0.54) 0.26 (0.11, 0.57) 0.27 (0.1, 0.52)
rate 0.072 (0.049, 0.105) 0.04 (0, 0.123) 0.131 (0.083, 0.283) 0.124 (0.077, 0.248) 0.124 (0.081, 0.224)
-+-+ graduation 0 479 445 443 448
futility 0 0 0 0 0
max_n 0 19 14 17 12
n 18 (10, 26) 2 (0, 8) 7 (2, 18) 7 (3, 19) 7 (3, 19)
n_unique 17 (9, 25) 2 (0, 8) 6 (2, 17) 7 (3, 18) 6 (3, 17)
post_p NA (NA, NA) 0.75 (0.44, 0.95) 0.28 (0.11, 0.52) 0.27 (0.09, 0.49) 0.27 (0.09, 0.55)
rate 0.071 (0.046, 0.101) 0.041 (0, 0.118) 0.126 (0.082, 0.285) 0.125 (0.082, 0.263) 0.124 (0.078, 0.251)
-++- graduation 0 407 259 285 309
futility 0 0 0 0 0
max_n 0 56 17 29 25
n 12 (8, 17) 2 (0, 8) 5 (1, 12) 5 (2, 13) 5 (2, 12)
n_unique 11 (7, 16) 2 (0, 8) 5 (1, 11) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.75 (0.46, 0.93) 0.35 (0.16, 0.62) 0.34 (0.14, 0.62) 0.34 (0.15, 0.61)
rate 0.075 (0.045, 0.123) 0.041 (0, 0.116) 0.13 (0.07, 0.325) 0.127 (0.074, 0.278) 0.127 (0.074, 0.312)
-+++ graduation 0 434 318 339 355
futility 0 0 0 0 0
max_n 0 56 17 23 22
n 12 (7, 16) 2 (0, 7) 4 (1, 12) 5 (2, 12) 5 (2, 12)
n_unique 11 (6, 16) 2 (0, 7) 4 (1, 11) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.75 (0.43, 0.95) 0.35 (0.16, 0.62) 0.34 (0.14, 0.61) 0.33 (0.14, 0.61)
rate 0.075 (0.042, 0.126) 0.041 (0, 0.117) 0.126 (0.07, 0.347) 0.123 (0.074, 0.295) 0.13 (0.074, 0.334)
+— graduation 0 291 105 87 102
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 21 (15, 29) 8 (1, 22) 8 (4, 18) 7 (3, 18) 7 (3, 17)
n_unique 20 (14, 27) 8 (1, 20) 7 (3, 17) 6 (2, 16) 7 (2, 16)
post_p NA (NA, NA) 0.86 (0.5, 0.99) 0.22 (0.08, 0.51) 0.26 (0.1, 0.56) 0.27 (0.1, 0.6)
rate 0.075 (0.05, 0.104) 0.04 (0.019, 0.089) 0.128 (0.082, 0.246) 0.129 (0.08, 0.327) 0.124 (0.075, 0.295)
+–+ graduation 0 358 239 224 237
futility 0 0 0 0 0
max_n 0 0 2 1 0
n 17 (11, 23) 5 (0, 15) 7 (3, 15) 6 (2, 15) 6 (2, 14)
n_unique 16 (11, 21) 4 (0, 15) 6 (3, 14) 5 (2, 14) 5 (2, 13)
post_p NA (NA, NA) 0.81 (0.48, 0.97) 0.28 (0.12, 0.59) 0.31 (0.14, 0.58) 0.3 (0.14, 0.6)
rate 0.074 (0.048, 0.11) 0.041 (0.017, 0.099) 0.12 (0.074, 0.25) 0.126 (0.073, 0.318) 0.123 (0.072, 0.317)
+-+- graduation 0 384 225 228 256
futility 0 0 0 0 0
max_n 0 57 17 31 25
n 17 (11, 23) 3 (0, 14) 7 (3, 15) 6 (2, 15) 6 (2, 15)
n_unique 16 (10, 22) 3 (0, 13) 6 (2, 14) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.8 (0.45, 0.97) 0.28 (0.11, 0.57) 0.3 (0.13, 0.59) 0.29 (0.14, 0.55)
rate 0.075 (0.05, 0.108) 0.041 (0.014, 0.102) 0.128 (0.074, 0.245) 0.126 (0.076, 0.309) 0.135 (0.08, 0.305)
+-++ graduation 0 421 299 308 327
futility 0 0 0 0 0
max_n 0 57 17 25 22
n 17 (11, 23) 3 (0, 12) 7 (3, 16) 6 (2, 15) 6 (2, 15)
n_unique 15 (10, 22) 3 (0, 11) 7 (3, 16) 6 (2, 13) 6 (2, 15)
post_p NA (NA, NA) 0.75 (0.43, 0.97) 0.29 (0.12, 0.62) 0.3 (0.13, 0.62) 0.27 (0.12, 0.56)
rate 0.073 (0.047, 0.114) 0.042 (0.016, 0.111) 0.122 (0.077, 0.251) 0.126 (0.075, 0.311) 0.134 (0.078, 0.353)
++– graduation 0 337 180 206 217
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 12 (7, 17) 3 (0, 11) 5 (2, 11) 5 (2, 11) 5 (2, 12)
n_unique 11 (7, 16) 3 (0, 10) 4 (2, 11) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.75 (0.44, 0.95) 0.33 (0.15, 0.62) 0.32 (0.14, 0.61) 0.34 (0.14, 0.62)
rate 0.073 (0.042, 0.124) 0.044 (0.013, 0.124) 0.131 (0.068, 0.354) 0.124 (0.075, 0.311) 0.125 (0.072, 0.31)
++-+ graduation 0 388 281 295 299
futility 0 0 0 0 0
max_n 0 0 2 1 0
n 12 (7, 17) 3 (0, 10) 5 (1, 11) 5 (2, 12) 5 (2, 12)
n_unique 11 (7, 17) 2 (0, 9) 4 (1, 10) 5 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.76 (0.5, 0.95) 0.34 (0.16, 0.63) 0.34 (0.15, 0.6) 0.34 (0.17, 0.6)
rate 0.075 (0.043, 0.126) 0.04 (0.011, 0.089) 0.128 (0.072, 0.382) 0.127 (0.073, 0.279) 0.131 (0.074, 0.277)
+++- graduation 0 407 259 285 309
futility 0 0 0 0 0
max_n 0 56 17 29 25
n 12 (7, 17) 2 (0, 8) 5 (1, 12) 6 (2, 12) 5 (2, 12)
n_unique 11 (7, 16) 1 (0, 8) 4 (1, 11) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.74 (0.42, 0.93) 0.35 (0.16, 0.64) 0.33 (0.16, 0.62) 0.31 (0.16, 0.6)
rate 0.073 (0.043, 0.122) 0.04 (0, 0.115) 0.128 (0.069, 0.342) 0.122 (0.075, 0.268) 0.127 (0.077, 0.326)
++++ graduation 0 434 318 339 355
futility 0 0 0 0 0
max_n 0 56 17 23 22
n 12 (7, 17) 2 (0, 8) 5 (1, 11) 5 (2, 12) 5 (2, 12)
n_unique 11 (7, 17) 1 (0, 7) 4 (1, 11) 5 (2, 12) 4 (2, 12)
post_p NA (NA, NA) 0.73 (0.41, 0.94) 0.37 (0.17, 0.65) 0.34 (0.16, 0.62) 0.33 (0.16, 0.57)
rate 0.074 (0.043, 0.122) 0.039 (0, 0.123) 0.127 (0.068, 0.366) 0.12 (0.07, 0.322) 0.125 (0.074, 0.301)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Carboplatin Niraparib
all count 291 1
time_stop 9 (4, 29) 6 (6, 6)
n_trt 63 (29, 190) 25 (25, 25)
n_control 89 (46, 326) 70 (70, 70)
post_p 1 (0.9, 1) 0.98 (0.98, 0.98)
order 1 (1, 3) 1 (1, 1)
TP53- & AR- count 342 1 2
time_stop 11 (7, 24) 15 (15, 15) 14 (12, 17)
n_trt 36 (26, 96) 37 (37, 37) 38 (31, 46)
n_control 45 (27, 111) 70 (70, 70) 60 (46, 74)
post_p 0.96 (0.89, 1) 0.85 (0.85, 0.85) 0.89 (0.88, 0.89)
order 1 (1, 2) 3 (3, 3) 2 (2, 2)
TP53+ count 216
time_stop 14 (9, 28)
n_trt 42 (27, 114)
n_control 60 (36, 145)
post_p 0.99 (0.93, 1)
order 2 (1, 3.5)
DRD+ count 108
time_stop 24 (17, 33)
n_trt 30 (25, 46)
n_control 66 (41, 98)
post_p 1 (0.96, 1)
order 3 (1, 4)
TEfus+ count 162
time_stop 20 (12, 32)
n_trt 38 (26, 83)
n_control 74 (39, 132)
post_p 1 (0.95, 1)
order 3 (1, 5)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 105 86 102
time_stop 30 (17, 36) 30 (20, 35) 31 (21, 36)
n_trt 116 (68, 193) 123 (72, 182) 114 (80, 197)
n_control 348 (184, 429) 342 (211, 424) 347 (245, 431)
post_p 0 (0, 0) 0 (0, 0) 0 (0, 0)
order 6 (2, 9) 6 (3, 9) 7 (4, 10)
TP53- & AR- count 2 402 406 419
time_stop 6 (5, 8) 21 (14, 32) 20 (13, 31) 21 (13, 32)
n_trt 26 (26, 27) 40 (25, 96) 38 (25, 102) 40 (25, 103)
n_control 26 (24, 27) 103 (61, 163) 93 (54, 162) 99 (55, 167)
post_p 0.27 (0.25, 0.29) 0.05 (0, 0.17) 0.05 (0, 0.18) 0.05 (0, 0.18)
order 1 (1, 1) 3 (1, 6) 3 (1, 6) 3 (1, 6.2)
TP53+ count 1 221 224 256
time_stop 9 (9, 9) 23 (12, 34) 25 (14, 34) 25 (14, 34)
n_trt 26 (26, 26) 55 (28, 103) 56 (29, 110) 53 (28, 102)
n_control 35 (35, 35) 119 (49, 185) 129 (62, 190) 122 (65, 186)
post_p 0.29 (0.29, 0.29) 0.01 (0, 0.08) 0.01 (0, 0.06) 0.01 (0, 0.07)
order 1 (1, 1) 4 (1, 9) 4 (1, 8) 4 (1, 9)
DRD+ count 162 201 215
time_stop 30 (20, 35) 25 (15, 34) 24 (14, 34)
n_trt 41 (26, 65) 44 (28, 62) 39 (26, 65)
n_control 90 (54, 117) 74 (41, 105) 70 (37, 111)
post_p 0.01 (0, 0.05) 0.01 (0, 0.09) 0.02 (0, 0.09)
order 6.5 (3, 11) 5 (2, 8) 5 (2, 9)
TEfus+ count 233 218 236
time_stop 25 (14, 34) 25 (16, 35) 25 (15, 34)
n_trt 52 (29, 82) 49 (29, 87) 46 (28, 84)
n_control 102 (48, 153) 105 (57, 150) 102 (54, 148)
post_p 0.01 (0, 0.06) 0.01 (0, 0.06) 0.01 (0, 0.07)
order 5 (1, 9) 5 (2, 9.3) 5 (2, 9)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 291 291 291 291 291 291 291 291 291 291 291 291 291 291 291 291
time 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29) 9 (4, 29)
n 22 (14, 58) 4 (1, 10) 13 (5, 44) 5 (1, 23) 1 (0, 6) 1 (0, 6) 1 (0, 5) 1 (0, 5) 3 (0, 12) 2 (0, 10) 2 (0, 9) 2 (0, 7) 1 (0, 6) 1 (0, 6) 1 (0, 5) 1 (0, 5)
post_p 0.81 (0.57, 1) 0.58 (0.52, 0.88) 0.74 (0.54, 1) 0.62 (0.52, 0.97) 0.63 (0.52, 0.94) 0.6 (0.52, 0.9) 0.61 (0.51, 0.87) 0.63 (0.52, 0.9) 0.59 (0.51, 0.94) 0.6 (0.51, 0.9) 0.6 (0.52, 0.88) 0.59 (0.52, 0.88) 0.6 (0.52, 0.87) 0.63 (0.52, 0.89) 0.61 (0.52, 0.87) 0.62 (0.52, 0.85)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.033 (0, 0.054) 0.016 (0, 0.077) 0.033 (0, 0.062) 0.024 (0, 0.071) 0 (0, 0.071) 0.006 (0, 0.069) 0 (0, 0.075) 0 (0, 0.064) 0.017 (0, 0.079) 0 (0, 0.073) 0 (0, 0.067) 0 (0, 0.076) 0 (0, 0.082) 0.016 (0, 0.079) 0 (0, 0.072) 0 (0, 0.06)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 4 (4, 4) 1 (1, 1) 1 (1, 1) 3 (3, 3) 5 (5, 5) 2 (2, 2) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 1 (1, 1) 2 (2, 2) 1 (1, 1)
post_p 0.64 (0.64, 0.64) 0.55 (0.55, 0.55) 0.54 (0.54, 0.54) 0.53 (0.53, 0.53) 0.63 (0.63, 0.63) 0.59 (0.59, 0.59) NA (NA, NA) 0.5 (0.5, 0.5) 0.63 (0.63, 0.63) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.5 (0.5, 0.5) NA (NA, NA) 0.6 (0.6, 0.6) 0.51 (0.51, 0.51)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 342 342 342 342
time 11 (7, 24) 11 (7, 24) 11 (7, 24) 11 (7, 24)
n 28 (20, 72) 4 (2, 11) 2 (0, 8) 2 (0, 8)
post_p 0.9 (0.74, 1) 0.59 (0.52, 0.82) 0.6 (0.52, 0.85) 0.58 (0.52, 0.85)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.037 (0.014, 0.051) 0.025 (0, 0.09) 0 (0, 0.086) 0 (0, 0.074)
Carboplatin count 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 25 (25, 25) 2 (2, 2) 5 (5, 5) 5 (5, 5)
post_p 0.77 (0.77, 0.77) 0.58 (0.58, 0.58) 0.56 (0.56, 0.56) 0.69 (0.69, 0.69)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.052 (0.052, 0.052) 0 (0, 0) 0.068 (0.068, 0.068) 0.028 (0.028, 0.028)
Niraparib count 2 2 2 2
time 14 (12, 17) 14 (12, 17) 14 (12, 17) 14 (12, 17)
n 24 (18, 30) 3 (2, 4) 8 (6, 11) 3 (3, 3)
post_p 0.83 (0.82, 0.84) 0.55 (0.54, 0.56) 0.8 (0.76, 0.84) 0.58 (0.57, 0.59)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.058 (0.045, 0.072) 0.05 (0.01, 0.09) 0.058 (0.044, 0.073) 0.079 (0.066, 0.092)
TP53+ Hormone_therapies count 216 216 216 216 216 216 216 216
time 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28) 14 (9, 28)
n 20 (12, 50) 9 (4, 27) 2 (0, 6) 2 (0, 5) 4 (1, 10) 3 (1, 8) 2 (0, 6) 2 (0, 6)
post_p 0.87 (0.72, 1) 0.78 (0.58, 0.97) 0.6 (0.52, 0.83) 0.61 (0.52, 0.84) 0.65 (0.52, 0.9) 0.62 (0.52, 0.85) 0.59 (0.52, 0.84) 0.6 (0.52, 0.84)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.035 (0.015, 0.057) 0.033 (0, 0.062) 0 (0, 0.074) 0 (0, 0.075) 0.015 (0, 0.072) 0.023 (0, 0.086) 0 (0, 0.08) 0 (0, 0.075)
DRD+ count 108 108 108 108 108 108 108 108
time 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33) 24 (17, 33)
n 4 (1, 10) 4 (1, 9) 3 (1, 7) 3 (1, 7) 5 (1, 10) 4 (1, 9) 3 (1, 8) 3 (0, 8)
post_p 0.77 (0.58, 0.97) 0.75 (0.53, 0.92) 0.68 (0.52, 0.89) 0.69 (0.53, 0.88) 0.73 (0.55, 0.93) 0.72 (0.54, 0.94) 0.71 (0.54, 0.88) 0.69 (0.53, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.031 (0, 0.079) 0.035 (0, 0.066) 0.029 (0, 0.088) 0.028 (0, 0.092) 0.03 (0, 0.084) 0.027 (0, 0.074) 0.032 (0, 0.085) 0.029 (0, 0.082)
TEfus+ count 162 162 162 162 162 162 162 162
time 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32) 20 (12, 32)
n 5 (2, 13) 12 (5, 31) 3 (0, 8) 3 (0, 6) 5 (2, 13) 4 (1, 10) 3 (1, 8) 2 (0, 7)
post_p 0.74 (0.52, 0.95) 0.85 (0.71, 0.99) 0.7 (0.53, 0.9) 0.64 (0.54, 0.87) 0.74 (0.54, 0.93) 0.71 (0.54, 0.93) 0.66 (0.53, 0.86) 0.64 (0.52, 0.87)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.037 (0, 0.083) 0.036 (0.013, 0.066) 0.032 (0, 0.072) 0.02 (0, 0.086) 0.03 (0, 0.073) 0.03 (0, 0.072) 0.019 (0, 0.082) 0.021 (0, 0.077)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Taxel_therapies count 105 105 105 105 105 105 105 105 105 105 105 105 105 105 105 105
time 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36) 30 (17, 36)
n 15 (7, 58) 6 (3, 14) 12 (5, 45) 10 (7, 28) 6 (2, 14) 5 (1, 15) 3 (0, 9) 3 (0, 9) 7 (3, 13) 5 (2, 10) 6 (2, 14) 5 (2, 11) 4 (1, 10) 4 (0, 10) 3 (0, 8) 3 (0, 7)
post_p 0.09 (0.01, 0.35) 0.31 (0.12, 0.48) 0.17 (0.04, 0.42) 0.21 (0.05, 0.41) 0.31 (0.09, 0.47) 0.28 (0.15, 0.46) 0.35 (0.19, 0.47) 0.38 (0.17, 0.48) 0.26 (0.1, 0.46) 0.28 (0.16, 0.46) 0.32 (0.17, 0.48) 0.28 (0.09, 0.47) 0.36 (0.19, 0.47) 0.35 (0.2, 0.48) 0.35 (0.19, 0.47) 0.35 (0.17, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.125 (0.092, 0.202) 0.13 (0.084, 0.248) 0.123 (0.09, 0.2) 0.121 (0.085, 0.189) 0.135 (0.094, 0.29) 0.139 (0.088, 0.285) 0.156 (0.085, 0.369) 0.153 (0.088, 0.383) 0.138 (0.081, 0.3) 0.151 (0.082, 0.329) 0.12 (0.076, 0.295) 0.151 (0.08, 0.291) 0.151 (0.083, 0.487) 0.146 (0.087, 0.439) 0.153 (0.084, 0.531) 0.172 (0.091, 0.64)
Carboplatin count 86 86 86 86 86 86 86 86 86 86 86 86 86 86 86 86
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 16 (8, 47) 5 (2, 13) 12 (5, 40) 9 (4, 28) 6 (3, 12) 6 (3, 12) 4 (2, 8) 4 (1, 8) 5 (2, 16) 4 (2, 8) 4 (1, 13) 4 (2, 11) 4 (2, 8) 4 (2, 10) 4 (2, 8) 4 (1, 7)
post_p 0.12 (0.02, 0.3) 0.31 (0.13, 0.46) 0.17 (0.05, 0.38) 0.22 (0.05, 0.43) 0.26 (0.11, 0.46) 0.29 (0.14, 0.44) 0.33 (0.16, 0.47) 0.34 (0.18, 0.47) 0.26 (0.12, 0.46) 0.32 (0.17, 0.44) 0.32 (0.16, 0.45) 0.32 (0.17, 0.47) 0.34 (0.17, 0.46) 0.33 (0.14, 0.47) 0.34 (0.2, 0.49) 0.34 (0.2, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.12 (0.093, 0.175) 0.132 (0.088, 0.282) 0.117 (0.089, 0.235) 0.129 (0.085, 0.242) 0.147 (0.09, 0.27) 0.135 (0.093, 0.304) 0.134 (0.079, 0.27) 0.137 (0.089, 0.277) 0.151 (0.085, 0.529) 0.148 (0.085, 0.374) 0.154 (0.096, 0.371) 0.149 (0.086, 0.324) 0.137 (0.08, 0.289) 0.153 (0.084, 0.415) 0.132 (0.086, 0.398) 0.132 (0.075, 0.388)
Niraparib count 102 102 102 102 102 102 102 102 102 102 102 102 102 102 102 102
time 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36) 31 (21, 36)
n 23 (10, 60) 5 (2, 13) 13 (5, 35) 8 (4, 28) 6 (3, 14) 6 (2, 12) 4 (1, 9) 4 (1, 9) 7 (3, 14) 4 (1, 13) 4 (2, 10) 4 (2, 11) 4 (2, 9) 4 (2, 8) 4 (2, 9) 4 (2, 8)
post_p 0.1 (0.01, 0.35) 0.34 (0.13, 0.46) 0.14 (0.03, 0.38) 0.21 (0.07, 0.44) 0.31 (0.11, 0.45) 0.25 (0.1, 0.44) 0.34 (0.17, 0.45) 0.3 (0.15, 0.46) 0.27 (0.13, 0.47) 0.32 (0.17, 0.47) 0.28 (0.14, 0.46) 0.28 (0.14, 0.45) 0.36 (0.14, 0.46) 0.35 (0.21, 0.48) 0.35 (0.2, 0.47) 0.33 (0.15, 0.46)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.113 (0.093, 0.153) 0.12 (0.085, 0.247) 0.125 (0.087, 0.255) 0.125 (0.087, 0.267) 0.129 (0.083, 0.211) 0.153 (0.091, 0.285) 0.169 (0.084, 0.513) 0.165 (0.092, 0.529) 0.124 (0.085, 0.289) 0.146 (0.083, 0.342) 0.154 (0.089, 0.42) 0.155 (0.093, 0.424) 0.133 (0.086, 0.4) 0.145 (0.082, 0.333) 0.147 (0.088, 0.343) 0.147 (0.084, 0.317)
TP53- & AR- Hormone_therapies count 2 2 2 2
time 6 (5, 8) 6 (5, 8) 6 (5, 8) 6 (5, 8)
n 20 (20, 21) 4 (4, 5) 0 (0, 1) 1 (0, 2)
post_p 0.34 (0.26, 0.41) 0.42 (0.42, 0.42) 0.42 (0.42, 0.42) 0.49 (0.49, 0.49)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.085 (0.07, 0.1) 0.173 (0.133, 0.213) 20.808 (20.808, 20.808) 0 (0, 0)
Taxel_therapies count 402 402 402 402
time 21 (14, 32) 21 (14, 32) 21 (14, 32) 21 (14, 32)
n 19 (9, 60) 6 (3, 14) 6 (2, 15) 6 (2, 15)
post_p 0.17 (0.02, 0.41) 0.35 (0.15, 0.48) 0.37 (0.16, 0.48) 0.38 (0.19, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.113 (0.086, 0.179) 0.121 (0.08, 0.247) 0.133 (0.086, 0.319) 0.131 (0.084, 0.324)
Carboplatin count 406 406 406 406
time 20 (13, 31) 20 (13, 31) 20 (13, 31) 20 (13, 31)
n 18 (9, 66) 5 (2, 14) 7 (3, 16) 7 (3, 15)
post_p 0.2 (0.02, 0.43) 0.37 (0.16, 0.48) 0.35 (0.14, 0.48) 0.37 (0.15, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.111 (0.087, 0.165) 0.132 (0.084, 0.368) 0.127 (0.084, 0.254) 0.124 (0.081, 0.285)
Niraparib count 419 419 419 419
time 21 (13, 32) 21 (13, 32) 21 (13, 32) 21 (13, 32)
n 21 (9, 66) 5 (2, 14) 7 (3, 15) 6 (3, 16)
post_p 0.19 (0.02, 0.43) 0.38 (0.15, 0.48) 0.36 (0.15, 0.48) 0.35 (0.14, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.112 (0.085, 0.181) 0.131 (0.082, 0.3) 0.128 (0.083, 0.227) 0.128 (0.085, 0.27)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 10 (10, 10) 11 (11, 11) 0 (0, 0) 3 (3, 3) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0)
post_p 0.44 (0.44, 0.44) 0.38 (0.38, 0.38) NA (NA, NA) 0.34 (0.34, 0.34) 0.43 (0.43, 0.43) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.073, 0.073) 0.058 (0.058, 0.058) NA (NA, NA) 0.233 (0.233, 0.233) 0.25 (0.25, 0.25) NA (NA, NA) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 221 221 221 221 221 221 221 221
time 23 (12, 34) 23 (12, 34) 23 (12, 34) 23 (12, 34) 23 (12, 34) 23 (12, 34) 23 (12, 34) 23 (12, 34)
n 12 (6, 39) 11 (6, 28) 3 (1, 9) 3 (0, 9) 5 (2, 12) 5 (3, 11) 3 (1, 8) 3 (0, 9)
post_p 0.18 (0.04, 0.41) 0.22 (0.05, 0.44) 0.39 (0.2, 0.48) 0.39 (0.22, 0.48) 0.34 (0.16, 0.47) 0.35 (0.14, 0.47) 0.39 (0.21, 0.48) 0.37 (0.21, 0.47)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.121 (0.087, 0.215) 0.121 (0.085, 0.2) 0.153 (0.086, 0.437) 0.15 (0.083, 0.356) 0.135 (0.079, 0.31) 0.133 (0.08, 0.281) 0.152 (0.086, 0.529) 0.162 (0.084, 0.566)
Carboplatin count 224 224 224 224 224 224 224 224
time 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34)
n 12 (5, 42) 10 (4, 29) 4 (2, 9) 4 (1, 9) 4 (2, 12) 5 (2, 11) 4 (2, 9) 4 (2, 9)
post_p 0.18 (0.05, 0.42) 0.27 (0.07, 0.47) 0.38 (0.17, 0.48) 0.37 (0.18, 0.48) 0.34 (0.16, 0.46) 0.35 (0.2, 0.47) 0.37 (0.22, 0.49) 0.36 (0.19, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.117 (0.085, 0.215) 0.12 (0.086, 0.267) 0.133 (0.078, 0.331) 0.14 (0.085, 0.329) 0.154 (0.086, 0.413) 0.143 (0.094, 0.417) 0.131 (0.083, 0.273) 0.139 (0.078, 0.37)
Niraparib count 256 256 256 256 256 256 256 256
time 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34)
n 13 (5, 37) 9 (3, 28) 4 (1, 9) 4 (2, 10) 4 (2, 12) 4 (1, 12) 4 (2, 8) 4 (2, 10)
post_p 0.19 (0.04, 0.43) 0.27 (0.07, 0.45) 0.38 (0.18, 0.48) 0.36 (0.16, 0.47) 0.36 (0.17, 0.47) 0.35 (0.13, 0.47) 0.38 (0.21, 0.48) 0.36 (0.18, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.12 (0.085, 0.229) 0.12 (0.086, 0.278) 0.137 (0.079, 0.435) 0.15 (0.077, 0.428) 0.142 (0.09, 0.418) 0.148 (0.089, 0.424) 0.144 (0.086, 0.348) 0.144 (0.078, 0.319)
DRD+ Taxel_therapies count 162 162 162 162 162 162 162 162
time 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35) 30 (20, 35)
n 7 (3, 15) 7 (2, 17) 4 (1, 9) 3 (1, 9) 5 (2, 9) 4 (1, 10) 3 (1, 8) 3 (1, 8)
post_p 0.33 (0.09, 0.46) 0.29 (0.14, 0.46) 0.36 (0.18, 0.48) 0.36 (0.17, 0.47) 0.37 (0.17, 0.47) 0.37 (0.2, 0.48) 0.36 (0.21, 0.47) 0.35 (0.18, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.13 (0.091, 0.282) 0.129 (0.088, 0.282) 0.157 (0.085, 0.434) 0.152 (0.088, 0.358) 0.138 (0.083, 0.334) 0.139 (0.086, 0.376) 0.151 (0.085, 0.458) 0.161 (0.092, 0.575)
Carboplatin count 201 201 201 201 201 201 201 201
time 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34)
n 6 (3, 14) 6 (3, 13) 4 (2, 9) 4 (2, 9) 5 (2, 9) 4 (2, 10) 4 (2, 8) 4 (2, 9)
post_p 0.31 (0.12, 0.47) 0.31 (0.11, 0.45) 0.36 (0.18, 0.48) 0.38 (0.18, 0.48) 0.37 (0.2, 0.47) 0.38 (0.16, 0.48) 0.38 (0.19, 0.48) 0.38 (0.21, 0.48)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.132 (0.087, 0.256) 0.128 (0.083, 0.309) 0.14 (0.082, 0.315) 0.136 (0.083, 0.323) 0.129 (0.078, 0.289) 0.148 (0.078, 0.358) 0.132 (0.085, 0.34) 0.129 (0.072, 0.39)
Niraparib count 215 215 215 215 215 215 215 215
time 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34) 24 (14, 34)
n 6 (3, 14) 6 (2, 13) 4 (2, 9) 4 (2, 9) 4 (2, 9) 4 (2, 8) 4 (2, 8) 4 (2, 9)
post_p 0.33 (0.12, 0.48) 0.3 (0.11, 0.46) 0.39 (0.2, 0.48) 0.36 (0.17, 0.48) 0.37 (0.18, 0.48) 0.36 (0.21, 0.48) 0.37 (0.2, 0.48) 0.36 (0.18, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.132 (0.089, 0.238) 0.144 (0.088, 0.285) 0.145 (0.075, 0.433) 0.149 (0.08, 0.436) 0.14 (0.081, 0.401) 0.148 (0.08, 0.323) 0.144 (0.087, 0.381) 0.14 (0.078, 0.368)
TEfus+ Taxel_therapies count 233 233 233 233 233 233 233 233
time 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34) 25 (14, 34)
n 6 (3, 14) 11 (6, 28) 6 (2, 15) 3 (1, 9) 6 (2, 10) 6 (3, 12) 4 (1, 9) 3 (1, 9)
post_p 0.34 (0.14, 0.47) 0.19 (0.05, 0.44) 0.35 (0.17, 0.47) 0.38 (0.2, 0.48) 0.32 (0.15, 0.47) 0.32 (0.14, 0.46) 0.38 (0.21, 0.48) 0.38 (0.21, 0.47)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.126 (0.08, 0.233) 0.119 (0.086, 0.198) 0.131 (0.084, 0.335) 0.143 (0.085, 0.381) 0.143 (0.079, 0.331) 0.136 (0.083, 0.253) 0.151 (0.081, 0.579) 0.154 (0.085, 0.513)
Carboplatin count 218 218 218 218 218 218 218 218
time 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35) 25 (16, 35)
n 5 (2, 13) 11 (4, 33) 6 (3, 13) 4 (2, 10) 4 (2, 10) 5 (2, 12) 4 (2, 11) 4 (2, 9)
post_p 0.33 (0.16, 0.46) 0.24 (0.05, 0.47) 0.31 (0.12, 0.46) 0.37 (0.18, 0.48) 0.36 (0.18, 0.48) 0.36 (0.17, 0.48) 0.36 (0.17, 0.47) 0.37 (0.19, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.135 (0.088, 0.369) 0.122 (0.087, 0.271) 0.129 (0.087, 0.32) 0.139 (0.081, 0.334) 0.14 (0.084, 0.405) 0.139 (0.084, 0.318) 0.144 (0.08, 0.339) 0.131 (0.075, 0.369)
Niraparib count 236 236 236 236 236 236 236 236
time 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34) 25 (15, 34)
n 5 (2, 12) 9 (4, 28) 6 (3, 16) 4 (1, 10) 5 (2, 13) 4 (2, 11) 4 (2, 8) 4 (2, 9)
post_p 0.35 (0.17, 0.48) 0.26 (0.09, 0.46) 0.32 (0.12, 0.46) 0.35 (0.16, 0.48) 0.37 (0.17, 0.48) 0.32 (0.13, 0.47) 0.37 (0.2, 0.48) 0.36 (0.18, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.125 (0.082, 0.25) 0.121 (0.085, 0.267) 0.134 (0.084, 0.272) 0.149 (0.08, 0.428) 0.131 (0.083, 0.343) 0.15 (0.089, 0.422) 0.143 (0.083, 0.323) 0.14 (0.083, 0.317)